Glutaraldehyde 및 Formocreso이 유견유치 치수조직에 미치는 영향에 관한 정리조직학적 연구
A Hirtopathological Study of Pulp Tissue Reactions to Glutaralhehyde and Formocresol in Puppy's Primary Teeth
소속 상세정보
허노정/No Jeong Hur
KMID : 0358919810080010037
Abstract
유견의 유치에서 생황치수절단술을 시행하고, formocresol, glutaraldehyde, calcium
hydroxide를 치수절단부에 적용하고 통법에 따라 치수복조를 시행한후, 2시간, 1주, 2주, 3
주, 5주군으로 각각 나누어, 치수의 약제에 대한 반응을 병리조직학적으로 관찰한 바 다음과
같은 결론을 얻었다.
1. formocresol과 glutaraldehyde실험군에서 석회화물질은 보이지 않고, 치수의 괴사를 보였
다.
2. 수산화칼슘 적용군에서는 1주군부터 상아교의 형성이 나타나고 3주군에서 거의 완료된
소견을 보였다.
3. formocresol실험군과 ghtaraldehyde실험군은 서로 반응기간, 조직변화상등이 유사하였다.
4. forimcresol과 glutarauehyde실험군에서 .2시간, 1주군에서 치수절단부 하부의 치수조직
이 응고성괴사를 보이고, 2주군부터는 응고성 괴사가 치근단방향으로 이행되고 염증세포의
침윤을 수반하며, 3주, 5주군에서는 화농과 액화성 괴사등이 보였다.
5. 화농된 치수는 유치 상아질의 흡수를 야기시키며 치근단주위의 조직에 염증상이 나타나
고 치근의 흡수를 보였다.
6. calcium hydroxide실험군에 비해 formocresol과 glutaraldehyde실험군에서 치근흡수가
심하였고, 사용된 약제가 영구치배에 미치는 영향은 관찰되지 않았다.
#초록#
This study was undertaken to evaluate the pulpal responses to the pulp-capping
materials such as glutaraldehyde and formocresol in pulpotomy technique, especially in
the primary dentition.
Mandibular primary canines and molars of 5 dogs (aged about 8-9 weeks) were
selected for this study. The intervals of observation for histologic study of pulpotomized
primary teeth with 2% glutaraldehyde, formocresol and calcium hydroxide in the usual
manner ranged from 2 hours, 1 week,2 weeks, 3 weeks and 5 weeks after experiments
respectively.
Each specimens were fixed with 10% formalin and decalcified in 5% nitric acid. All
slides were stained with Hematorylin-Eosin and examined histopathologically.
The results were as follows;
1. In calcium hydroxide groups, formation of dentin bridge was initiated in 1 week
after experiments and completed in 5 weeks after experiments.
2. Formation of dentin bridge was not seen, whereas necrosis of pulp tissue was noted,
in forgocresol and glutaraldehyde groups.
3. Duration of tissue reactions and tissue changes were similar, in formocresol and
glutaralhehyde groups.
4. In formocresol and glutaraldehyde groups, amputation surfaces of the pulp were
covered with blood dots, beneath which coagulation necrois was noted, but inflammatory
cells were not prominent, in 2 hours and 1 week after experiments. But coagulation
necrosis was proceeded to the apical portion, accompanied by infiltration of inflammatory
cells, since 2 weeks after experiments. And suppuration or gangrene of the pulp tissue
were noted in 3 weeks and 5 weeks groups.
5. Suppuration or gangrene of pulp seemed to provoke the resorption of dentin wall,
and inflammatory changes and resorption of roots were noted in the periodontal
membrane near the periapical region.
6. As compared with calcium hydroxide groups, resorption of the root was pronounced
in formorcresol and glutaraldehyde groups. Effects of medicaments to the succedaneovs
tooth germ were not seen.
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